Posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with genetic defect of MTHFR C677T

J Child Neurol. 2009 Jul;24(7):891-4. doi: 10.1177/0883073808331081.

Abstract

Cerebral artery occlusion in childhood, particularly in the posterior circulation, is a rare neurological complication of Mycoplasma pneumoniae infection. A genetic defect in the methylenetetrahydrofolate reductase gene could result in hyperhomocysteinemia and increased risk of stroke. We report a patient with posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with a homozygous, methylenetetrahydrofolate reductase gene mutant type.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Brain / blood supply
  • Brain / pathology
  • Diffusion Magnetic Resonance Imaging
  • Humans
  • Infarction, Posterior Cerebral Artery / etiology*
  • Infarction, Posterior Cerebral Artery / genetics*
  • Infarction, Posterior Cerebral Artery / pathology
  • Magnetic Resonance Angiography
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Mutation, Missense
  • Mycoplasma Infections / complications*
  • Mycoplasma pneumoniae*
  • Sequence Analysis, DNA

Substances

  • Methylenetetrahydrofolate Reductase (NADPH2)