Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes

Orthopedics. 2009 Jun;32(6):411. doi: 10.3928/01477447-20090511-08.

Abstract

The etiology of adolescent idiopathic scoliosis is undetermined despite years of research. A number of hypotheses have been postulated to explain its development, including growth abnormalities. The irregular expression of growth hormone and insulin-like growth factor-1 (IGF-1) may disturb hormone metabolism, result in a gross asymmetry, and promote the progress of adolescent idiopathic scoliosis. Initial association studies in complex diseases have demonstrated the power of candidate gene association. Prior to our study, 1 study in this field had a negative result. A replicable study is vital for reliability. To determine the relationship of growth hormone receptor and IGF-1 genes with adolescent idiopathic scoliosis, a population-based association study was performed. Single nucleotide polymorphisms with potential function were selected from candidate genes and a distribution analysis was performed. A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • China / epidemiology
  • Female
  • Genetic Predisposition to Disease / epidemiology*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Incidence
  • Insulin-Like Growth Factor I / genetics*
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Somatotropin / genetics*
  • Risk Assessment / methods
  • Risk Factors
  • Scoliosis / epidemiology*
  • Scoliosis / genetics*
  • Young Adult

Substances

  • Receptors, Somatotropin
  • Insulin-Like Growth Factor I