Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression

Fertil Steril. 2010 Jan;93(1):325-7. doi: 10.1016/j.fertnstert.2009.06.042. Epub 2009 Jul 31.

Abstract

Lipopolysaccharide-enhanced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production were compared in endometriotic stromal cells (ESCs) and eutopic endometrial stromal cells. Lipopolysaccharide promotes the proliferation and invasion of ESCs via up-regulation of COX-2 and PGE2 expression, suggesting that pelvic inflammation may promote the progression of endometriosis.

MeSH terms

  • Case-Control Studies
  • Cell Movement / drug effects*
  • Cell Proliferation / drug effects*
  • Cells, Cultured
  • Cyclooxygenase 2 / biosynthesis*
  • Cyclooxygenase 2 / genetics
  • Cyclooxygenase 2 Inhibitors / pharmacology
  • Dinoprostone / metabolism
  • Dose-Response Relationship, Drug
  • Endometriosis / enzymology*
  • Endometriosis / pathology
  • Endometrium / drug effects*
  • Endometrium / enzymology
  • Endometrium / pathology
  • Enzyme Induction
  • Female
  • Humans
  • Lipopolysaccharides / pharmacology*
  • Nitrobenzenes / pharmacology
  • Ovarian Diseases / enzymology*
  • Ovarian Diseases / pathology
  • RNA Interference
  • RNA, Messenger / metabolism
  • Stromal Cells / drug effects*
  • Stromal Cells / enzymology
  • Stromal Cells / pathology
  • Sulfonamides / pharmacology
  • Time Factors

Substances

  • Cyclooxygenase 2 Inhibitors
  • Lipopolysaccharides
  • Nitrobenzenes
  • RNA, Messenger
  • Sulfonamides
  • lipopolysaccharide, E coli O55-B5
  • N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Dinoprostone