Abstract
Lipopolysaccharide-enhanced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production were compared in endometriotic stromal cells (ESCs) and eutopic endometrial stromal cells. Lipopolysaccharide promotes the proliferation and invasion of ESCs via up-regulation of COX-2 and PGE2 expression, suggesting that pelvic inflammation may promote the progression of endometriosis.
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Case-Control Studies
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Cell Movement / drug effects*
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Cell Proliferation / drug effects*
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Cells, Cultured
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Cyclooxygenase 2 / biosynthesis*
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Cyclooxygenase 2 / genetics
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Cyclooxygenase 2 Inhibitors / pharmacology
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Dinoprostone / metabolism
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Dose-Response Relationship, Drug
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Endometriosis / enzymology*
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Endometriosis / pathology
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Endometrium / drug effects*
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Endometrium / enzymology
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Endometrium / pathology
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Enzyme Induction
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Female
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Humans
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Lipopolysaccharides / pharmacology*
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Nitrobenzenes / pharmacology
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Ovarian Diseases / enzymology*
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Ovarian Diseases / pathology
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RNA Interference
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RNA, Messenger / metabolism
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Stromal Cells / drug effects*
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Stromal Cells / enzymology
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Stromal Cells / pathology
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Sulfonamides / pharmacology
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Time Factors
Substances
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Cyclooxygenase 2 Inhibitors
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Lipopolysaccharides
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Nitrobenzenes
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RNA, Messenger
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Sulfonamides
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lipopolysaccharide, E coli O55-B5
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N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
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Cyclooxygenase 2
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PTGS2 protein, human
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Dinoprostone