COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia

H Magnus Haraldsson; Ulrich Ettinger; Brynja B Magnusdottir; Thordur Sigmundsson; Engilbert Sigurdsson; Andres Ingason; Hannes Petursson

doi:10.1016/j.psychres.2008.10.003

COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia

Psychiatry Res. 2009 Sep 30;169(2):173-5. doi: 10.1016/j.psychres.2008.10.003. Epub 2009 Jul 31.

Authors

H Magnus Haraldsson¹, Ulrich Ettinger, Brynja B Magnusdottir, Thordur Sigmundsson, Engilbert Sigurdsson, Andres Ingason, Hannes Petursson

Affiliation

¹ Division of Psychiatry, Landspitali-University Hospital, Reykjavik, Iceland. hmagnus@landspitali.is

PMID: 19647329
DOI: 10.1016/j.psychres.2008.10.003

Abstract

The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Analysis of Variance
Catechol O-Methyltransferase / genetics*
DNA Mutational Analysis
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Male
Methionine / genetics*
Middle Aged
Neuropsychological Tests
Ocular Motility Disorders / etiology
Ocular Motility Disorders / genetics*
Polymorphism, Single Nucleotide*
Psychiatric Status Rating Scales
Pursuit, Smooth / genetics*
Reaction Time
Schizophrenia / complications
Schizophrenia / genetics
Valine / metabolism*

Substances

Methionine
Catechol O-Methyltransferase
Valine