[GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients]

N N Chakova; E P Mikhalenko; S N Polonetskaia; N V Chebotareva; Iu E Demidchik; A A Zhilko; O V Kvitko; E V Krupnova

[GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients]

Tsitol Genet. 2009 Jan-Feb;43(1):48-53.

[Article in Russian]

Authors

N N Chakova, E P Mikhalenko, S N Polonetskaia, N V Chebotareva, Iu E Demidchik, A A Zhilko, O V Kvitko, E V Krupnova

PMID: 19663315

Abstract

Carriers of GSTTI gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTTI(-). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.

Publication types

English Abstract

MeSH terms

Carcinoma, Non-Small-Cell Lung / enzymology
Carcinoma, Non-Small-Cell Lung / etiology
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / pathology
Cytogenetic Analysis
DNA / genetics
Gene Deletion*
Genetic Predisposition to Disease
Glutathione Transferase / genetics*
Homozygote
Humans
Lung / enzymology
Lung / pathology
Lung Neoplasms / enzymology
Lung Neoplasms / etiology
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Micronuclei, Chromosome-Defective*
Middle Aged
Polymorphism, Genetic*
Risk
Smoking / adverse effects

Substances

DNA
glutathione S-transferase T1
Glutathione Transferase
glutathione S-transferase M1