MicroRNAs and parallel stem cell lives

Cell. 2009 Aug 7;138(3):423-4. doi: 10.1016/j.cell.2009.07.025.

Abstract

A new study by Shimono et al. (2009) demonstrates that certain microRNAs that regulate the self-renewal factor BMI1 are downregulated in purified populations of normal mammary epithelial stem cells and breast tumor-initiating cells. These findings have important implications for the regulation of self-renewal and differentiation by microRNAs and suggest new ways of targeting cancer stem cells.

Publication types

  • Comment

MeSH terms

  • Breast / cytology
  • Breast Neoplasms / genetics
  • Down-Regulation
  • Humans
  • MicroRNAs / metabolism*
  • Neoplastic Stem Cells / cytology
  • Neoplastic Stem Cells / metabolism*
  • Nuclear Proteins / genetics
  • Polycomb Repressive Complex 1
  • Proto-Oncogene Proteins / genetics
  • Repressor Proteins / genetics
  • Stem Cells / cytology
  • Stem Cells / metabolism*

Substances

  • BMI1 protein, human
  • MicroRNAs
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Polycomb Repressive Complex 1