Abstract
Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1]. The TRUC (T-bet-/- RAG2-/- ulcerative colitis) model is discussed in the broader context of the adaptive and innate immune mechanisms that regulate host-commensal relationships within the intestine.
MeSH terms
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Animals
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DNA-Binding Proteins* / genetics
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DNA-Binding Proteins* / immunology
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Dendritic Cells / immunology
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Homeostasis / immunology*
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Humans
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Immune System Phenomena / immunology
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Inflammatory Bowel Diseases* / immunology
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Inflammatory Bowel Diseases* / microbiology
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Intestinal Mucosa / immunology
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Intestinal Mucosa / microbiology
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Intestinal Mucosa / pathology
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Mice
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Mice, Knockout
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T-Box Domain Proteins* / genetics
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T-Box Domain Proteins* / immunology
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T-Lymphocytes, Regulatory / immunology
Substances
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DNA-Binding Proteins
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Rag2 protein, mouse
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T-Box Domain Proteins
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T-box transcription factor TBX21