IGF-1: elixir for motor neuron diseases

Theodora Papanikolaou; Lisa M Ellerby

doi:10.1016/j.neuron.2009.07.024

IGF-1: elixir for motor neuron diseases

Neuron. 2009 Aug 13;63(3):277-8. doi: 10.1016/j.neuron.2009.07.024.

Authors

Theodora Papanikolaou¹, Lisa M Ellerby

Affiliation

¹ The Buck Institute for Age Research, Novato, CA 94945, USA.

PMID: 19679066
DOI: 10.1016/j.neuron.2009.07.024

Abstract

Modulation of testosterone levels is a therapeutic approach for spinal and bulbar muscular atrophy (SBMA), a polyglutamine disorder that affects the motor neurons. The article by Palazzolo et al. in this issue of Neuron provides compelling evidence that the expression of insulin growth hormone is a potential therapeutic for SBMA.

Publication types

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MeSH terms

Animals
Disease Models, Animal
Humans
Insulin-Like Growth Factor I / genetics
Insulin-Like Growth Factor I / metabolism*
Motor Neuron Disease / genetics
Motor Neuron Disease / metabolism*
Motor Neuron Disease / pathology
Motor Neuron Disease / therapy*
Muscle, Skeletal / metabolism

Substances

Insulin-Like Growth Factor I