Abstract
Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5' region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z=9.18; p<1 x 10(-3)). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Case-Control Studies
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DNA Mutational Analysis
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Female
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Gene Frequency
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Genetic Predisposition to Disease*
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Genotype
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Humans
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Linkage Disequilibrium
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Male
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Middle Aged
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Odds Ratio
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Polymorphism, Single Nucleotide / genetics*
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Protein Serine-Threonine Kinases / genetics
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Receptors, GABA-A / genetics*
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Schizophrenia / genetics*
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Young Adult
Substances
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GABRG2 protein, human
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Receptors, GABA-A
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Protein Serine-Threonine Kinases