Gender effects on association of serotonin transporter gene polymorphism with symptoms of central fatigue

N V Maluchenko; J V Schegolkova; M A Kulikova; M A Timofeeva; V A Shlepcova; O V Sysoeva; A G Tonevitsky

doi:10.1007/s10517-009-0559-2

Gender effects on association of serotonin transporter gene polymorphism with symptoms of central fatigue

Bull Exp Biol Med. 2009 Apr;147(4):462-5. doi: 10.1007/s10517-009-0559-2.

[Article in English, Russian]

Authors

N V Maluchenko¹, J V Schegolkova, M A Kulikova, M A Timofeeva, V A Shlepcova, O V Sysoeva, A G Tonevitsky

Affiliation

¹ Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. mal_nat@mail.ru

PMID: 19704949
DOI: 10.1007/s10517-009-0559-2

Abstract

In order to test the "serotonin" hypothesis of the genesis of central fatigue, we studied association between genotype and fatigue (3-hour mental workload consisting of information processing and logical task solution) using analysis of variance for different indices (well-being, activity, mood, mental fatigue index). It was concluded that young men with serotonin deficit (LL genotype) and girls with serotonin excess (S genotype) were less tolerant to long-lasting mental workload. Thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Affect
Alleles
Analysis of Variance
Fatigue / genetics*
Female
Humans
Male
Mental Processes*
Neuropsychological Tests
Polymorphism, Genetic*
Psychological Tests
Serotonin Plasma Membrane Transport Proteins / genetics*
Sex Characteristics*
Surveys and Questionnaires
Young Adult

Substances

SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins