Major histocompatibility complex class I and class II polymorphism in chronic idiopathic demyelinating polyradiculoneuropathy

R W Vaughan; A M Adam; I A Gray; R A Hughes; E A Sanders; M van Dam; K I Welsh

doi:10.1016/0165-5728(90)90064-t

Major histocompatibility complex class I and class II polymorphism in chronic idiopathic demyelinating polyradiculoneuropathy

J Neuroimmunol. 1990 May;27(2-3):149-53. doi: 10.1016/0165-5728(90)90064-t.

Authors

R W Vaughan¹, A M Adam, I A Gray, R A Hughes, E A Sanders, M van Dam, K I Welsh

Affiliation

¹ Department of Molecular Immunogenetics, United Medical School, Guy's Hospital, London, U.K.

PMID: 1970579
DOI: 10.1016/0165-5728(90)90064-t

Abstract

Thirty-one chronic idiopathic demyelinating polyradiculoneuropathy (CIDP) patients have been typed for HLA-A, -B and -C antigens serologically and for HLA-DR, -DQ and -DP class II genes by RFLP analysis. Our results confirm a previously reported slight association with HLA-B8 and identify a stronger association with HLA-Cw7.

MeSH terms

Adult
Aged
Chronic Disease
Demyelinating Diseases / immunology*
Female
HLA Antigens / genetics*
HLA-D Antigens / genetics*
Humans
Male
Middle Aged
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Polyradiculoneuropathy / genetics
Polyradiculoneuropathy / immunology*

Substances

HLA Antigens
HLA-D Antigens