Abstract
Castleman disease (CD) is a rare lymphoproliferative disorder of unknown etiology. It is quite difficult to diagnose CD without typical localized signs or symptoms. We present a 5-year-old boy with unicentric plasma cell CD in the mesentery, which was too small to be detected by any conventional imaging. (18)F-fluorodeoxyglucose positron emission tomography image and a serum cytokine profile prompted us to perform a curative surgical excision, confirming his diagnosis. Our case also supported an important role of interleukin-6 in the pathophysiology of plasma cell CD.
Publication types
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Case Reports
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Castleman Disease / blood
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Castleman Disease / diagnosis*
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Castleman Disease / diagnostic imaging
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Castleman Disease / physiopathology
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Castleman Disease / surgery
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Child, Preschool
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Fever / etiology
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Fluorine Radioisotopes
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Fluorodeoxyglucose F18
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Humans
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Interleukin-6 / blood*
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Interleukin-6 / genetics
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Interleukin-6 / physiology
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Lymph Node Excision
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Male
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Mesentery / diagnostic imaging*
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Plasma Cells / pathology
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Positron-Emission Tomography*
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Radiopharmaceuticals
Substances
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Fluorine Radioisotopes
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IL6 protein, human
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Interleukin-6
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Radiopharmaceuticals
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Fluorodeoxyglucose F18