Abstract
Loss of BRCA1 has been shown to expand breast stem cells. In Nature Medicine, Lim et al. (2009) demonstrate that breast tissue from BRCA1 mutation carriers contains expanded luminal progenitor cells, suggesting a broader role for BRCA1 in mammary development.
MeSH terms
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Animals
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BRCA1 Protein / deficiency*
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology*
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Cell Differentiation
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Disease Models, Animal
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Female
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Gene Dosage
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Humans
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Mammary Glands, Human / cytology
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Mice
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Stem Cells / cytology