Abstract
Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.
Publication types
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Clinical Trial
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Multicenter Study
MeSH terms
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Adult
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Analysis of Variance
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Antidepressive Agents / therapeutic use*
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Depressive Disorder, Major / drug therapy*
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Depressive Disorder, Major / genetics*
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Female
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Gene Frequency
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Genetic Predisposition to Disease*
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Genome-Wide Association Study
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Genotype
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Humans
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Male
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Middle Aged
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Pharmacogenetics*
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Polymorphism, Single Nucleotide / genetics*
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Psychiatric Status Rating Scales
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Receptor, Serotonin, 5-HT2A / genetics
Substances
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Antidepressive Agents
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Receptor, Serotonin, 5-HT2A