Abstract
With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Biphenyl Compounds / chemical synthesis*
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / pharmacology
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Cell Differentiation / drug effects
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HL-60 Cells
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Humans
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K562 Cells
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Ketones / chemical synthesis*
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Ketones / chemistry
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Ketones / pharmacology
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology
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Structure-Activity Relationship
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Terphenyl Compounds / chemical synthesis*
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Terphenyl Compounds / chemistry
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Terphenyl Compounds / pharmacology
Substances
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Antineoplastic Agents
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Biphenyl Compounds
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Ketones
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Proto-Oncogene Proteins c-bcl-2
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Spiro Compounds
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Terphenyl Compounds