Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder

Neurosci Lett. 2009 Nov 27;466(1):27-9. doi: 10.1016/j.neulet.2009.09.019. Epub 2009 Sep 17.

Abstract

Neuregulin (NRG) 1Ialpha and NRG3 proteins levels were measured in Brodmann's area 46 from 20 subjects with schizophrenia, 8 subjects with bipolar 1 disorder and 20 age-sex matched control subjects. Protein levels of both NRG1Ialpha and NRG3 were unchanged in both psychiatric illnesses. These data suggest any change in NRG1Ialpha and NRG3 expression in schizophrenia or bipolar 1 disorder do not result in changes levels in levels of those proteins Brodmann's area 46.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bipolar Disorder / metabolism*
  • Humans
  • Neuregulin-1 / genetics
  • Neuregulin-1 / metabolism*
  • Neuregulins / genetics
  • Neuregulins / metabolism*
  • Prefrontal Cortex / metabolism*
  • Protein Isoforms
  • Schizophrenia / metabolism*

Substances

  • NRG1 protein, human
  • NRG3 protein, human
  • Neuregulin-1
  • Neuregulins
  • Protein Isoforms