Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics

Cancer Genet Cytogenet. 2009 Oct 15;194(2):111-8. doi: 10.1016/j.cancergencyto.2009.06.010.

Abstract

Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Base Sequence
  • Chromosomes, Human, Pair 16*
  • Chromosomes, Human, Pair 21*
  • Cytogenetic Analysis
  • DNA Mutational Analysis
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • Oncogene Proteins, Fusion / isolation & purification
  • RNA, Messenger / genetics
  • RNA, Messenger / isolation & purification
  • RNA-Binding Protein FUS / genetics*
  • RNA-Binding Protein FUS / isolation & purification
  • Translocation, Genetic*

Substances

  • Oncogene Proteins, Fusion
  • RNA, Messenger
  • RNA-Binding Protein FUS
  • TLS-ERG fusion protein, human