Common variants in polygenic schizophrenia

Joseph T Glessner; Hakon Hakonarson

doi:10.1186/gb-2009-10-9-236

Common variants in polygenic schizophrenia

Genome Biol. 2009;10(9):236. doi: 10.1186/gb-2009-10-9-236. Epub 2009 Sep 29.

Authors

Joseph T Glessner¹, Hakon Hakonarson

Affiliation

¹ Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Abstract

Common variant single-nucleotide polymorphisms at the MHC locus have recently been associated with schizophrenia. Together with known associations with rare copy-number variants affecting many genes, this reveals the highly polygenic etiology of the disease.

Publication types

Review

MeSH terms

Genetic Predisposition to Disease*
Genetic Variation
Genome-Wide Association Study
Humans
Major Histocompatibility Complex / genetics
Meta-Analysis as Topic
Multifactorial Inheritance / genetics*
Polymorphism, Single Nucleotide*
Proto-Oncogene Proteins / genetics
Receptor, Notch4
Receptors, Notch / genetics
Schizophrenia / genetics*

Substances

NOTCH4 protein, human
Proto-Oncogene Proteins
Receptor, Notch4
Receptors, Notch