Synergistic effects of ACE (I/D) and ApoE (HhaI) gene polymorphisms among the adult Asian Indians with and without metabolic syndrome

Diabetes Res Clin Pract. 2009 Dec;86(3):e58-61. doi: 10.1016/j.diabres.2009.09.011. Epub 2009 Oct 2.

Abstract

A total of 350 (184 males and 166 females) adults participated in the study. A sample of 138 individuals was selected randomly for genotyping. The synergistic effect of ACE (I/D) and ApoE (HhaI) on metabolic syndrome (MS) showed that individuals with e4/4+D/D combination had the highest occurrence of metabolic abnormalities.

MeSH terms

  • Adult
  • Apolipoproteins E / genetics*
  • Asian People / genetics
  • Blood Pressure
  • Body Mass Index
  • DNA / blood
  • DNA / genetics
  • DNA / isolation & purification
  • Dyslipidemias / epidemiology
  • Dyslipidemias / genetics
  • Female
  • Genotype
  • Humans
  • Hypertension / epidemiology
  • India
  • Lipids / blood
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / enzymology
  • Metabolic Syndrome / genetics*
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Genetic*
  • Waist-Hip Ratio

Substances

  • Apolipoproteins E
  • Lipids
  • DNA
  • Peptidyl-Dipeptidase A