Manic depressive illness not linked to factor IX region in an independent series of pedigrees

P V Gejman; S Detera-Wadleigh; M M Martinez; W H Berrettini; L R Goldin; J Gelernter; W T Hsieh; E S Gershon

doi:10.1016/0888-7543(90)90251-o

Manic depressive illness not linked to factor IX region in an independent series of pedigrees

Genomics. 1990 Dec;8(4):648-55. doi: 10.1016/0888-7543(90)90251-o.

Authors

P V Gejman¹, S Detera-Wadleigh, M M Martinez, W H Berrettini, L R Goldin, J Gelernter, W T Hsieh, E S Gershon

Affiliation

¹ Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892.

PMID: 1980485
DOI: 10.1016/0888-7543(90)90251-o

Abstract

We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below -2 in the region extending from about 10 cM centromeric from the Factor IX locus (F9) to the colorblindness region. This study does not replicate previous reports of linkage of MDI to Factor IX (Xq27) and colorblindness region (Xq28) chromosomal markers in other kindreds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bipolar Disorder / genetics*
Factor IX / genetics*
Female
Genetic Linkage*
Humans
Lod Score
Male
Pedigree
Phenotype
Polymorphism, Restriction Fragment Length
X Chromosome*

Substances

Factor IX