Abstract
Cytokines and hormones are essential mediators in the regulation of antimicrobial peptide and protein (AMP) levels during host defense responses. In this issue, Büchau et al. identify and characterize B-cell leukemia-3 as an important modulator of AMP expression during the innate immune response in keratinocytes as well as in the chronic inflammatory skin disorder atopic dermatitis.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Antimicrobial Cationic Peptides / genetics
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Antimicrobial Cationic Peptides / physiology
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B-Cell Lymphoma 3 Protein
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Cathelicidins
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Dermatitis, Atopic / etiology*
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Dermatitis, Atopic / immunology
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Dermatitis, Atopic / therapy
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Humans
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Immunity, Innate
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Keratinocytes / immunology
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Proto-Oncogene Proteins / physiology*
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Transcription Factors / physiology*
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Vitamin D / administration & dosage
Substances
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Antimicrobial Cationic Peptides
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B-Cell Lymphoma 3 Protein
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BCL3 protein, human
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Proto-Oncogene Proteins
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Transcription Factors
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Vitamin D
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Cathelicidins