Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples

Psychiatry Res. 2010 Jan 30;175(1-2):176-8. doi: 10.1016/j.psychres.2009.08.005. Epub 2009 Nov 5.

Abstract

Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Chi-Square Distribution
  • Family Health*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study / methods
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic / genetics*
  • Receptors, Serotonin, 5-HT4 / genetics*
  • Schizophrenia / genetics*

Substances

  • Receptors, Serotonin, 5-HT4