Preclinical mouse models for BRCA1-associated breast cancer

R M Drost; J Jonkers

doi:10.1038/sj.bjc.6605350

Preclinical mouse models for BRCA1-associated breast cancer

Br J Cancer. 2009 Nov 17;101(10):1651-7. doi: 10.1038/sj.bjc.6605350. Epub 2009 Sep 29.

Authors

R M Drost¹, J Jonkers

Affiliation

¹ Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands.

Abstract

A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human BRCA1-related breast cancer and may therefore be useful for addressing clinically relevant questions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Breast Neoplasms / genetics*
Disease Models, Animal*
Female
Genes, BRCA1*
Humans
Mammary Neoplasms, Experimental / genetics*
Mice
Mice, Knockout