Background: Serine protease inhibitor member 3 of clade A (SERPINA3) has been shown as a risk factor for aneurysmal subarachnoid hemorrhage in a Polish population. In the present study, the authors investigated the correlation between the rs4934 polymorphism of SERPINA3 and sporadic intracranial aneurysms in Chinese patients.
Methods: The rs4934 polymorphism of SERPINA3 was identified by PCR and Taqman MGB probe analysis in genomic DNA from 275 patients with sporadic intracranial aneurysms (mean age 50.83 +/- 10.78 years) and 361 control participants (mean age 53.21 +/- 10.81 years). Differences in allelic and genotypic frequencies between the patient and control groups were evaluated with the chi(2) test.
Results: No significant difference was found in either the genotype distribution or allelic frequencies of SERPINA3 between patients and controls.
Conclusions: The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity.