Genotype and haplotype determination of interleukin (IL) 1 beta (g. -511C>T and g. +3954C>T) and IL-1RN in polycystic ovary syndrome

Fertil Steril. 2010 Jun;94(1):384-6. doi: 10.1016/j.fertnstert.2009.09.042. Epub 2009 Nov 11.

Abstract

The distribution of genotype frequencies, allele frequencies, and haplotype frequencies of variable number of tandem repeats (VNTR) in interleukin (IL) 1RN and IL-1beta (-511C > T, exon-5C.>T) polymorphism demonstrated a positive association with the occurrence of polycystic ovary syndrome (PCOS). The carriage of allele V of IL-1RN and allele E1 of exon-5 on the IL-1beta gene may increase the risk of PCOS.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes / genetics*
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / genetics*
  • Interleukin-1beta / genetics*
  • Minisatellite Repeats / genetics
  • Polycystic Ovary Syndrome / diagnosis
  • Polycystic Ovary Syndrome / genetics*

Substances

  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1beta