Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?

M I Koenders; W B van den Berg

doi:10.1111/j.1365-2249.2009.04039.x

Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?

Clin Exp Immunol. 2010 Feb;159(2):131-6. doi: 10.1111/j.1365-2249.2009.04039.x. Epub 2009 Nov 11.

Authors

M I Koenders¹, W B van den Berg

Affiliation

¹ Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.

Abstract

In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / immunology*
Autoimmune Diseases / metabolism
Autoimmunity / immunology*
Encephalomyelitis, Autoimmune, Experimental / genetics
Encephalomyelitis, Autoimmune, Experimental / immunology
Encephalomyelitis, Autoimmune, Experimental / metabolism
Humans
Interleukin-17 / genetics
Interleukin-17 / immunology*
Interleukin-17 / metabolism
Mice
Mice, Knockout
T-Lymphocytes, Helper-Inducer / cytology
T-Lymphocytes, Helper-Inducer / immunology*
T-Lymphocytes, Helper-Inducer / metabolism

Substances

Interleukin-17