Telomerase gene mutation screening in Chinese patients with aplastic anemia

Bing Han; Bo Liu; Wei Cui; Xuan Wang; Jie Lin; Yongqiang Zhao

doi:10.1016/j.leukres.2009.11.001

Telomerase gene mutation screening in Chinese patients with aplastic anemia

Leuk Res. 2010 Feb;34(2):258-60. doi: 10.1016/j.leukres.2009.11.001. Epub 2009 Nov 25.

Authors

Bing Han¹, Bo Liu, Wei Cui, Xuan Wang, Jie Lin, Yongqiang Zhao

Affiliation

¹ Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1, Shuai Fuyuan, Dongcheng District, Beijing 100730, China. hanbing_li@sina.com.cn

PMID: 19942288
DOI: 10.1016/j.leukres.2009.11.001

Abstract

To study the incidence of telomerase gene mutations in Chinese patients with acquired bone marrow failure (BMF) and explore its relationship with telomere shortening. Blood samples from 66 patients with aplastic anemia (AA) in northern China were collected and TERC mutation analysis was performed. Two TERC mutations were identified. The incidence of telomerase gene mutations in Chinese people with acquired AA is similar to that of the western people.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Aplastic / enzymology
Anemia, Aplastic / genetics*
Bone Marrow Diseases
China / epidemiology
DNA Mutational Analysis
Gene Frequency
Humans
Incidence
Mutation*
Telomerase / genetics*
Telomere / ultrastructure

Substances

TERT protein, human
Telomerase