Metastasis: wherefore arf thou?

Curr Biol. 2009 Dec 1;19(22):R1036-8. doi: 10.1016/j.cub.2009.10.032.

Abstract

The small GTP-binding protein Arf6 is known to be an important regulator of the actin cytoskeleton and of cell motility associated with metastasis. A recent study identifies yet another role for Arf6 in metastasis - as a regulator of plasma-membrane-derived microvesicle release.

Publication types

  • Comment

MeSH terms

  • ADP-Ribosylation Factor 6
  • ADP-Ribosylation Factors / genetics
  • ADP-Ribosylation Factors / physiology*
  • Animals
  • Genes, Lethal
  • Humans
  • Mice
  • Mice, Knockout
  • Neoplasm Metastasis / physiopathology*
  • Signal Transduction

Substances

  • ADP-Ribosylation Factor 6
  • ADP-Ribosylation Factors
  • ARF6 protein, human
  • Arf6 protein, mouse