Ocular motor and imaging abnormalities of midbrain dysfunction in osmotic demyelination syndrome

Kristen M Hawthorne; Christopher J Compton; Michael S Vaphiades; Glenn H Roberson; Lanning B Kline

doi:10.1097/WNO.0b013e3181c25390

Ocular motor and imaging abnormalities of midbrain dysfunction in osmotic demyelination syndrome

J Neuroophthalmol. 2009 Dec;29(4):296-9. doi: 10.1097/WNO.0b013e3181c25390.

Authors

Kristen M Hawthorne¹, Christopher J Compton, Michael S Vaphiades, Glenn H Roberson, Lanning B Kline

Affiliation

¹ Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, USA.

PMID: 19952903
DOI: 10.1097/WNO.0b013e3181c25390

Abstract

After rapid correction of severe hyponatremia, a 36-year-old man developed osmotic demyelination syndrome (ODS), manifested neurologically by impaired cognition, extremity weakness, bilateral third cranial nerve palsies, and gaze-evoked upbeat and rotary nystagmus. Brain MRI showed restricted diffusion in the rostral midbrain and temporal and parietal lobes but not in the pons. Over several weeks, all neurologic and imaging deficits resolved. This is the first report to document ocular motor abnormalities associated with midbrain dysfunction in ODS.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blepharoptosis / complications
Blepharoptosis / physiopathology
Cognition Disorders / complications
Cognition Disorders / physiopathology
Electrolytes / adverse effects
Humans
Hyponatremia / complications
Hyponatremia / drug therapy
Magnetic Resonance Imaging
Male
Mesencephalon / physiopathology*
Myelinolysis, Central Pontine / chemically induced
Myelinolysis, Central Pontine / complications
Myelinolysis, Central Pontine / physiopathology*
Ocular Motility Disorders / complications*
Ocular Motility Disorders / physiopathology
Treatment Outcome

Substances

Electrolytes