Objective: To analyze a presumed association of gene polymorphism of killer cell immunoglobulin-like receptor three domains, long cytoplasmic tail, 2(KIR3DL2) gene with pre-eclampsia.
Methods: The KIR3DL2 gene A52G in exon 3 and C32T in exon 9 polymorphism were determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) in 95 pre-eclampsia and 91 normal pregnant women.
Results: There was significant difference between two group in exon 3 in terms of genotypes and allele (P < 0.05). There was a significant difference between two groups regarding the frequencies of exon 9 CC, CT and TT genotypes (P < 0.05). But no significant difference was found between mild pre-eclampsia and severe pre-eclampsia groups in terms of the two SNP loci (P > 0.05).
Conclusion: The A52G polymorphism in exon 3 and the frequencies of C32T in exon 9 of KIR3DL2 gene polymorphism are associated with the pathogenesis of pre-eclampsia, But it has no correlation with the severity of preeclampsia.