Objective: To study the relationship between neuropeptide Y2 receptor (NPY2R) gene rs1047214 polymorphism and obesity or metabolic syndrome in Chinese children and adolescents, in order to provide theoretical evidence for obesity control.
Methods: 2030 students at the age from 7 to 18 years were selected in Beijing. Physical indicators, blood pressure, serum lipids and fasting blood glucose and the rs1047214 polymorphism in NPY2R gene were tested for all the subjects.
Results: The mutation rate of the rs1047214 polymorphism (T>C) was 18.6% and the CC genotype frequency was significantly higher in non-obese subjects (3.7%) than that in obese subjects (1.7%) (P<0.05). The differences of BMI, waist circumference (WC), waist-hip ratio (WHR) and waist-to-height ratio (WtHR) were statistically significant among the subjects with CC genotype having lower BMI, WC, WHR and WtHR than CT+TTcarriers (P<0.05), shown in males, but not in females. There were no statistical significances for WC, WHR or WtHR levels between different genotypes under the general linear regression model, after adjusted for BMI. There were no statistical significances for blood pressure, serum lipids and FPG level between different genotypes.
Conclusion: The mutation rate of the rs1047214 polymorphism in NPY2R gene in Chinese adolescents was higher than that in foreign populations. Polymorphism seemed to be associated with obesity in males but did not seem to have significant association between polymorphism and other phenotypes of metabolic syndrome.