Abstract
Hepatitis C virus (HCV) is resistant to the antiviral cytokine type I interferon, representing a major clinical problem. Garaigorta and Chisari (2009) reveal that HCV uses the activation of the ds-RNA-dependent protein kinase R, which phosphorylates and inhibits the translation initiation factor eIF-2 alpha, to block translation of interferon-stimulated genes.
MeSH terms
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Hepacivirus / physiology*
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Hepatitis C / enzymology*
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Hepatitis C / genetics
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Hepatitis C / metabolism
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Hepatitis C / virology
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Humans
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Interferon Regulatory Factors / genetics
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Interferon Regulatory Factors / metabolism*
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Interferon Type I / metabolism
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Phosphorylation
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eIF-2 Kinase / genetics
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eIF-2 Kinase / metabolism*
Substances
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Interferon Regulatory Factors
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Interferon Type I
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eIF-2 Kinase