The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

Alexey V Polonikov; Sergey L Yarosh; Elena V Kokhtenko; Nina I Starodubova; Sergey P Pakhomov; Valentina S Orlova

doi:10.1016/j.fertnstert.2009.11.006

The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

Fertil Steril. 2010 Aug;94(3):1144-7. doi: 10.1016/j.fertnstert.2009.11.006. Epub 2010 Jan 13.

Authors

Alexey V Polonikov¹, Sergey L Yarosh, Elena V Kokhtenko, Nina I Starodubova, Sergey P Pakhomov, Valentina S Orlova

Affiliation

¹ Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia. polonikov@rambler.ru

PMID: 20056207
DOI: 10.1016/j.fertnstert.2009.11.006

Abstract

This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia.

MeSH terms

Adult
Case-Control Studies
Gene Deletion
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Glutathione Transferase / genetics*
Glutathione Transferase / physiology
Humans
Infertility, Male / genetics*
Male
Polymorphism, Genetic
Risk
Russia
Young Adult

Substances

glutathione S-transferase T1
Glutathione Transferase
glutathione S-transferase M1