FANCM: A landing pad for the Fanconi Anemia and Bloom's Syndrome complexes

Mol Cell. 2009 Dec 25;36(6):916-7. doi: 10.1016/j.molcel.2009.12.007.

Abstract

In this issue of Molecular Cell, Deans and West (2009) reveal the molecular basis of the phenotypic similarities between Fanconi Anemia (FA) and Bloom's Syndrome, identifying FANCM as the anchor for both FA and Bloom's complexes at the site of the DNA interstrand crosslink.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural

MeSH terms

  • Bloom Syndrome* / genetics
  • Bloom Syndrome* / metabolism
  • DNA Damage
  • DNA Helicases / genetics
  • DNA Helicases / metabolism*
  • DNA Repair
  • Fanconi Anemia* / genetics
  • Fanconi Anemia* / metabolism
  • Humans
  • Phenotype
  • RecQ Helicases / genetics
  • RecQ Helicases / metabolism

Substances

  • Bloom syndrome protein
  • FANCM protein, human
  • DNA Helicases
  • RecQ Helicases