Abstract
Increasing evidence supports the prognostic relevance of specific immunoglobulin heavy chain variable (IGHV) genes or stereotyped B-cell receptors (BCR) in chronic lymphocytic leukemia (CLL). The clonotypic BCRs differ in their specificity and affinity toward classical antigens and/or superantigens. The BCR-triggered mechanisms are distinct but could explain in part the different clinical behavior among CLL subgroups.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Gene Expression Regulation, Leukemic
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Gene Rearrangement / genetics*
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Humans
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Immunoglobulin Class Switching / genetics
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Immunoglobulin Heavy Chains / genetics*
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Immunoglobulin Heavy Chains / immunology
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Immunoglobulin Variable Region / genetics*
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Immunoglobulin Variable Region / immunology
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics
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Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
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Lymphocyte Activation / genetics
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Models, Biological
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Receptors, Antigen, B-Cell / genetics
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Receptors, Antigen, B-Cell / immunology
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Receptors, Antigen, B-Cell / metabolism
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Superantigens / immunology*
Substances
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Immunoglobulin Heavy Chains
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Immunoglobulin Variable Region
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Receptors, Antigen, B-Cell
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Superantigens