Objective: To investigate the association between polymorphism of beta(1)-adrenoceptor genes and cardiovascular complication in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients.
Method: The Gly389Arg polymorphism of beta(1)-adrenoceptor genes was identified by polymerase chain reaction-restricted fragment length polymorphism assay in 192 OSAHS patients of "Han" population of China. The effect of polymorphisms in the OSAHS group on parameters of polysomnography and cardiovascular complication was analyzed. Analysis of variance, t test and chi-square test were used for statistics.
Result: The distributions with CC genotype were significantly higher than those with CG/GG genotype. The frequencies with C allele were significantly higher than those with G allele. The OSAHS patients with CC genotype had higher percentage of time of oxygen saturation lower than 90% (T90) and longer apnea time (Tmax) than those with CG/GG genotype. The lowest saturation of blood oxygen (minSaO2) in patients with CC genotype was significantly lower than that in patients with CG/GG genotype. Cardiovascular diseases (P < 0.05) except sinus bradycardia were more common in patients with the CC genotype(P < 0.05).
Conclusion: The Gly389Arg CC genotype of beta(1)-adrenoceptor genes may be involved in cardiovascular complication in OSAHS, and the C allele may be an important candidate gene.