Abstract
Genetic peculiarities particularly xenobiotic detoxification enzymes play important role in pulmonary diseases development. The study was aimed to analyze gene polymorphisms for first (CYP1A1, CYP2E1, EPHX1) and second (GSTM1, GSTT1) phases of xenobiotics biotransformation in relation to occupational respiratory diseases risk.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adult
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Biotransformation / genetics*
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Cytochrome P-450 CYP1A1 / genetics
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Cytochrome P-450 CYP2E1 / genetics
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DNA / genetics
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Dust*
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Epoxide Hydrolases / genetics
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Genetic Predisposition to Disease
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Genotype
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Glutathione Transferase / genetics
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Humans
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Occupational Diseases / enzymology*
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Occupational Diseases / genetics
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Occupational Exposure / adverse effects*
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Polymorphism, Genetic
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Prognosis
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Respiratory Tract Diseases / enzymology*
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Respiratory Tract Diseases / genetics
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Risk Factors
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Xenobiotics / adverse effects*
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Xenobiotics / metabolism
Substances
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Dust
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Xenobiotics
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DNA
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Cytochrome P-450 CYP2E1
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Cytochrome P-450 CYP1A1
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glutathione S-transferase T1
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Glutathione Transferase
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glutathione S-transferase M1
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Epoxide Hydrolases
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EPHX1 protein, human