Deregulation of H3K27 methylation in cancer

Nat Genet. 2010 Feb;42(2):100-1. doi: 10.1038/ng0210-100.

Abstract

A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.

Publication types

  • News
  • Comment

MeSH terms

  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • Enhancer of Zeste Homolog 2 Protein
  • Germinal Center / metabolism
  • Germinal Center / pathology
  • Histones / metabolism*
  • Humans
  • Lymphoma, Follicular / genetics*
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Lysine / metabolism*
  • Methylation
  • Mutation / genetics
  • Polycomb Repressive Complex 2
  • Transcription Factors / chemistry
  • Transcription Factors / genetics

Substances

  • DNA-Binding Proteins
  • Histones
  • Transcription Factors
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2
  • Lysine