[Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele]

Hong-Xia Liang; Zu-Jiang Yu; He-Qing Jiang

[Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Aug;23(4):302-3.

[Article in Chinese]

Authors

Hong-Xia Liang¹, Zu-Jiang Yu, He-Qing Jiang

Affiliation

¹ Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

PMID: 20108780

Abstract

Objective: To investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene.

Methods: HLA-DRB1 * 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer (PCR-SSP) technique.

Results: The frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group.

Conclusion: HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Female
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Hepatitis B, Chronic / genetics*
Humans
Liver Cirrhosis / genetics*
Male

Substances

HLA-DR Antigens
HLA-DRB1 Chains