Abstract
The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Alcohol Drinking / epidemiology*
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Alcohol Drinking / genetics
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Alcoholic Beverages / adverse effects
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Alcoholic Beverages / classification
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Alcoholic Beverages / statistics & numerical data
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Arylamine N-Acetyltransferase / genetics*
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Biotransformation / genetics
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Carcinogens / pharmacokinetics
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Case-Control Studies
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Connecticut / epidemiology
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Cytochrome P-450 Enzyme System / genetics*
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Female
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Genetic Association Studies
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Genetic Predisposition to Disease
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Glutathione Transferase / genetics*
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Humans
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Lymphoma, Non-Hodgkin / enzymology
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Lymphoma, Non-Hodgkin / epidemiology*
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Lymphoma, Non-Hodgkin / genetics
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Middle Aged
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Polymorphism, Single Nucleotide*
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Risk
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Smoking / adverse effects
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Smoking / epidemiology
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Smoking / genetics
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Young Adult
Substances
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Carcinogens
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Cytochrome P-450 Enzyme System
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Arylamine N-Acetyltransferase
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Glutathione Transferase