FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

Y Niwa; D P Potaczek; S Kanada; A Takagi; N Shimokawa; T Ito; K Mitsuishi; Y Okubo; M Tajima; A Hobo; W Ng; R Tsuboi; S Ikeda; H Ogawa; K Okumura; C Nishiyama

doi:10.1111/j.1744-313X.2010.00901.x

FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

Int J Immunogenet. 2010 Apr;37(2):139-41. doi: 10.1111/j.1744-313X.2010.00901.x. Epub 2010 Feb 5.

Authors

Y Niwa¹, D P Potaczek, S Kanada, A Takagi, N Shimokawa, T Ito, K Mitsuishi, Y Okubo, M Tajima, A Hobo, W Ng, R Tsuboi, S Ikeda, H Ogawa, K Okumura, C Nishiyama

Affiliation

¹ Atopy (Allergy) Research Center, Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.

PMID: 20141544
DOI: 10.1111/j.1744-313X.2010.00901.x

Abstract

Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the -315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of -315CT/TT genotype or the -315T allele was significantly higher in those with highly elevated total serum IgE concentrations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Asian People / genetics
Dermatitis, Atopic / blood
Dermatitis, Atopic / ethnology
Dermatitis, Atopic / genetics*
Female
Gene Frequency
Genotype
Humans
Immunoglobulin E / blood*
Japan
Male
Middle Aged
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic / genetics*
Receptors, IgE / genetics*
Young Adult

Substances

FCER1A protein, human
Receptors, IgE
Immunoglobulin E