Bacterial invasion: linking autophagy and innate immunity

Lorenzo Galluzzi; Oliver Kepp; Laurence Zitvogel; Guido Kroemer

doi:10.1016/j.cub.2009.12.016

Bacterial invasion: linking autophagy and innate immunity

Curr Biol. 2010 Feb 9;20(3):R106-8. doi: 10.1016/j.cub.2009.12.016.

Authors

Lorenzo Galluzzi¹, Oliver Kepp, Laurence Zitvogel, Guido Kroemer

Affiliation

¹ INSERM, U848, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France.

PMID: 20144769
DOI: 10.1016/j.cub.2009.12.016

Abstract

Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.

MeSH terms

Animals
Autophagy / genetics
Autophagy / immunology*
Autophagy / physiology
Autophagy-Related Proteins
Bacterial Infections / immunology*
Bacterial Infections / physiopathology*
Carrier Proteins / genetics
Carrier Proteins / physiology
Crohn Disease / genetics
Crohn Disease / immunology
Crohn Disease / physiopathology
Humans
Immunity, Innate* / genetics
Immunity, Innate* / physiology
Models, Biological
Mutation
Nod2 Signaling Adaptor Protein / genetics
Nod2 Signaling Adaptor Protein / physiology
Signal Transduction

Substances

ATG16L1 protein, human
Autophagy-Related Proteins
Carrier Proteins
NOD2 protein, human
Nod2 Signaling Adaptor Protein