Abstract
Phosphatidylinositol (4,5) bisphosphate is a lipid second messenger that controls diverse cellular processes. Phosphatidylinositolphosphate-5-kinases synthesise this lipid at the plasma membrane, although it is not clear how the localisation of these kinases is controlled. A recent study suggests that the intrinsic surface charge of the plasma membrane may be an important factor.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Cell Membrane / metabolism*
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Phagocytosis / physiology*
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Phosphatidylinositol 4,5-Diphosphate
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Phosphatidylinositol Phosphates / biosynthesis*
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Phosphotransferases (Alcohol Group Acceptor) / metabolism*
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Second Messenger Systems / physiology*
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Static Electricity
Substances
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Phosphatidylinositol 4,5-Diphosphate
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Phosphatidylinositol Phosphates
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Phosphotransferases (Alcohol Group Acceptor)
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1-phosphatidylinositol-4-phosphate 5-kinase