Lipid kinases: charging PtdIns(4,5)P2 synthesis

Curr Biol. 2010 Feb 23;20(4):R154-7. doi: 10.1016/j.cub.2010.01.016.

Abstract

Phosphatidylinositol (4,5) bisphosphate is a lipid second messenger that controls diverse cellular processes. Phosphatidylinositolphosphate-5-kinases synthesise this lipid at the plasma membrane, although it is not clear how the localisation of these kinases is controlled. A recent study suggests that the intrinsic surface charge of the plasma membrane may be an important factor.

Publication types

  • Review

MeSH terms

  • Cell Membrane / metabolism*
  • Phagocytosis / physiology*
  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates / biosynthesis*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • Second Messenger Systems / physiology*
  • Static Electricity

Substances

  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates
  • Phosphotransferases (Alcohol Group Acceptor)
  • 1-phosphatidylinositol-4-phosphate 5-kinase