Hairy-related transcription factor 2 is not potentially related to congenital heart disease in Chinese patients

Binbin Wang; Shiyi Zhou; Qiuhong Chen; XiaoDong Xie; Guoying Huang; Jing Wang; Sirui Zhoua; Xu Ma

doi:10.1016/j.ijcard.2009.12.013

Hairy-related transcription factor 2 is not potentially related to congenital heart disease in Chinese patients

Int J Cardiol. 2011 Feb 3;146(3):415-6. doi: 10.1016/j.ijcard.2009.12.013. Epub 2010 Feb 24.

Authors

Binbin Wang¹, Shiyi Zhou, Qiuhong Chen, XiaoDong Xie, Guoying Huang, Jing Wang, Sirui Zhoua, Xu Ma

Affiliation

¹ Graduate school, Peking Union Medical College, Beijing, China.

PMID: 20181399
DOI: 10.1016/j.ijcard.2009.12.013

Abstract

Congenital heart disease (CHD) is the malformation of the heart during embryonic development, contributing to the inadequate function of the heart. A recently suggested gene hairy-related transcription factor 2 (HEY2), is an important determinant of mammalian heart development and functions thereby. We had preformed a direct sequencing within 768 Chinese CHD patients in the HEY2 gene. However, we did not reveal any diagnostic alterations in the coding regions by direct sequencing in HEY2, nevertheless this work expands our knowledge of the causes of CHD in the other way.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Basic Helix-Loop-Helix Transcription Factors / genetics*
China
Heart Defects, Congenital / genetics*
Heart Diseases / congenital*
Heart Diseases / genetics*
Humans
Repressor Proteins / genetics*

Substances

Basic Helix-Loop-Helix Transcription Factors
HEY2 protein, human
Repressor Proteins