Abstract
Porcine plasma and factor VIII preparations were screened for parvovirus 4 (PARV)-like viruses. Although the prevalence of PARV4-like viruses in plasma samples was relatively low, viruses appeared to be concentrated during manufacture of factor VIII. PARV4-like viruses from human and porcine origins coevolved likewise with their hosts.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Products / analysis*
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Biological Products / blood
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DNA, Viral / analysis
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Factor VIII / analysis*
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Factor VIII / therapeutic use
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Humans
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Parvoviridae Infections / blood*
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Parvoviridae Infections / virology
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Parvovirus / classification
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Parvovirus / genetics
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Parvovirus / isolation & purification*
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Plasma / virology*
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Sequence Analysis, DNA
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Swine
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Swine Diseases / virology
Substances
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Biological Products
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DNA, Viral
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Factor VIII