Abstract
Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoE-binding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age of Onset
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Alzheimer Disease / genetics*
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Asian People
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Brain / metabolism
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Chromosomes, Human, Pair 1 / genetics
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Exons
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Genetic Predisposition to Disease*
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Humans
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Introns
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LDL-Receptor Related Proteins
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Polymorphism, Genetic*
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Receptors, LDL / physiology
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Receptors, Lipoprotein / genetics*
Substances
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LDL-Receptor Related Proteins
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Receptors, LDL
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Receptors, Lipoprotein
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VLDL receptor
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low density lipoprotein receptor-related protein 8