Abstract
The chromatin structure is important for recognition and repair of DNA damage. Many DNA damage response proteins accumulate in large chromatin domains flanking sites of DNA double-strand breaks. The assembly of these structures-usually termed DNA damage foci-is primarily regulated by MDC1, a large nuclear mediator/adaptor protein that is composed of several distinct structural and functional domains. Here, we are summarizing the latest discoveries about the mechanisms by which MDC1 mediates DNA damage foci formation, and we are reviewing the considerable efforts taken to understand the functional implication of these structures.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Cell Cycle Proteins
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Chromatin / metabolism*
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DNA Breaks, Double-Stranded
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DNA Damage* / genetics
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DNA Repair* / genetics
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DNA-Binding Proteins / metabolism
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DNA-Binding Proteins / physiology
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Histones / chemistry
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Histones / metabolism
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Humans
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Intracellular Signaling Peptides and Proteins / chemistry
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Intracellular Signaling Peptides and Proteins / physiology*
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Mice
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Mitosis
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Nuclear Proteins / chemistry
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Nuclear Proteins / physiology*
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Protein Interaction Domains and Motifs
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Signal Transduction
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Trans-Activators / chemistry
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Trans-Activators / physiology*
Substances
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Adaptor Proteins, Signal Transducing
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Cell Cycle Proteins
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Chromatin
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DNA-Binding Proteins
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H2AX protein, human
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H2AX protein, mouse
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Histones
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Intracellular Signaling Peptides and Proteins
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MDC1 protein, human
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MDC1 protein, mouse
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Nuclear Proteins
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Trans-Activators