Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension

Pharmacogenomics. 2010 Mar;11(3):319-25. doi: 10.2217/pgs.09.158.

Abstract

Aims: To analyze the association of haplotypes of the adrenergic system with essential hypertension and with the blood pressure response to beta-blockers.

Materials & methods: In 1112 never-treated essential hypertension patients and 203 normotensive controls, tightly linked SNPs of beta-adrenergic receptors (ADRB1 - Ser49Gly and Arg389Gly; ADRB2 - Cys19Arg, Gly16Arg and Gln27Glu) and the G-protein beta3-subunit (GNB3 - A3882C, G5249A and C825T) were genotyped. Association of haplotypes with essential hypertension and with the blood pressure response to atenolol 50 mg twice daily in a subgroup of essential hypertension patients (n = 340) was evaluated (Haploview 3.2).

Results: No SNPs or haplotypes were associated with essential hypertension. In females only, GNB3 SNPs and haplotypes were associated with the blood pressure response (p < 0.05).

Conclusion: Our study confirmed the sex-specific association of GNB3 with the blood pressure response to atenolol with no substantial advantage of the analysis of haplotypes over SNPs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Adult
  • Aged
  • Atenolol / pharmacology
  • Base Sequence
  • Blood Pressure / drug effects*
  • Blood Pressure / genetics*
  • Case-Control Studies
  • DNA Primers / genetics
  • Female
  • Genetic Association Studies
  • Haplotypes*
  • Heterotrimeric GTP-Binding Proteins / genetics*
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / genetics*
  • Hypertension / physiopathology
  • Middle Aged
  • Pharmacogenetics
  • Polymorphism, Single Nucleotide
  • Receptors, Adrenergic, beta-1 / genetics*
  • Receptors, Adrenergic, beta-2 / genetics*

Substances

  • ADRB1 protein, human
  • Adrenergic beta-Antagonists
  • DNA Primers
  • G-protein beta3 subunit
  • Receptors, Adrenergic, beta-1
  • Receptors, Adrenergic, beta-2
  • Atenolol
  • Heterotrimeric GTP-Binding Proteins