Abstract
We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Chromosomes, Human, Pair 10 / genetics*
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Chromosomes, Human, Pair 11 / genetics*
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Flow Cytometry
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Gene Rearrangement
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Humans
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Immunophenotyping
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Infant
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Karyotyping
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Leukemia, Biphenotypic, Acute / genetics*
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Leukemia, Biphenotypic, Acute / pathology
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Leukemia, Biphenotypic, Acute / therapy
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Leukemia, Monocytic, Acute / genetics*
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Leukemia, Monocytic, Acute / pathology
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Leukemia, Monocytic, Acute / therapy
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Male
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Myeloid-Lymphoid Leukemia Protein / genetics*
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Neoplasm, Residual / genetics
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Neoplasm, Residual / pathology
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Neoplasm, Residual / therapy
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Oncogene Proteins, Fusion / genetics*
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Phenotype
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
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Prognosis
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Remission Induction
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Translocation, Genetic / genetics*
Substances
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MLL-AF10 fusion protein, human
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Oncogene Proteins, Fusion
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Myeloid-Lymphoid Leukemia Protein