Mucinous cystadenocarcinoma of the breast with amplification of the HER2-gene confirmed by FISH: The first case reported

Fredrik Petersson; Brendan Pang; Thomas P Thamboo; Thomas Choudary Putti

doi:10.1016/j.humpath.2009.10.020

Mucinous cystadenocarcinoma of the breast with amplification of the HER2-gene confirmed by FISH: The first case reported

Hum Pathol. 2010 Jun;41(6):910-3. doi: 10.1016/j.humpath.2009.10.020. Epub 2010 Mar 24.

Authors

Fredrik Petersson¹, Brendan Pang, Thomas P Thamboo, Thomas Choudary Putti

Affiliation

¹ Department of Pathology, National University Health System, Singapore 119074, Singapore. fredrikpetersson@live.se

PMID: 20338619
DOI: 10.1016/j.humpath.2009.10.020

Abstract

We present the first case of a primary mucinous cystadenocarcinoma of the breast that, in addition to the characteristic immunophenotype (CK7(+), CK20(-), ER(-), PR(-), and cdx2(-)), showed a strong membranous HER2-protein expression and HER2-gene amplification documented by fluorescence in situ hybridization.

Publication types

Case Reports

MeSH terms

Aged
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Cystadenocarcinoma, Mucinous / metabolism*
Cystadenocarcinoma, Mucinous / pathology
Female
Genes, erbB-2
Humans
In Situ Hybridization, Fluorescence
Receptor, ErbB-2 / biosynthesis*
Receptor, ErbB-2 / genetics

Substances

ERBB2 protein, human
Receptor, ErbB-2